Methodology

How we grade evidence

Every intervention on the site carries two ranks. The evidence grade (A–D) summarizes the underlying clinical evidence: A requires replicated RCTs on hard outcomes; D is mechanistic or anecdotal. The tier (S–D) is the all-things-considered recommendation, factoring in cost, access, effort, and time-to-effect. The same intervention can sit at different tiers on different biomarker pages — that is intentional.

The full evidence rubric is being written and will live on this page.

Rubric page in progress.